Evaluation of Diastolic Heart Function Using Echocardiography and Pulse Wave Analysis in Patients After Anthracycline Therapy



Year of publication 2021
Type Article in Proceedings
Conference Computing in Cardiology 2021
MU Faculty or unit

Faculty of Medicine

Web https://ieeexplore.ieee.org/document/9662816
Doi http://dx.doi.org/10.23919/CinC53138.2021.9662816
Keywords echocardiography; pulse wave analysis; diastolic function
Description Introduction Diastolic dysfunction plays a crucial role in heart failure. In clinical practice, the standard cardiac examination is echocardiography, where pulse Doppler analysis is used to evaluate diastolic function. The similar parameters could be measured by applanation tonometry. The aim of this study was to determine the correlation between the parameters of diastolic heart function measured by echocardiography and obtained by pulse wave analysis. Methods The study included 92 subjects (41 females) who had been previously treated with anthracycline antibiotics. Pulse waves were registered by the applanation tonometry (Sphygmocor; AtCor Medical, Australia). Each measurement being calibrated by oscillometric method of blood pressure measurement (Omron HEM-907-E instrument, Japan). From the pulse wave we obtained the values of systolic pressure (SBP) and diastolic pressure (DBP), Tension-Time Index (TTI), Diastolic Time Index (DTI) and Subendocardial Viability Ratio (SEVR). With echocardiographic examination (Nemio XG, TOSHIBA, Japan) were estimated parameters of diastolic heart function: E - mitral peak early diastolic filling velocity, A - peak left ventricular filling during atrial contraction, E / A - the ratio of the velocity E a A in left ventricle, IRT - isovolumic relaxation time, DT - deceleration time. Results All measured values were in the physiological range. We found a statistically significant correlation between IRT and DTI, between A, E / A and SEVR. We did not find a significant correlation between the parameters of diastolic function and age or time since the end of treatment. Conclusion From the observed correlation between echocardiography and applanation tonometry, we can assume that the SEVR parameter is suitable for the assessment of diastolic heart function.
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