Medical algorithm: Diagnosis and management of antibody immunodeficiencies
| Authors | |
|---|---|
| Year of publication | 2021 |
| Type | Article in Periodical |
| Magazine / Source | Allergy |
| MU Faculty or unit | |
| Citation | |
| Web | https://onlinelibrary.wiley.com/doi/10.1111/all.14961 |
| Doi | http://dx.doi.org/10.1111/all.14961 |
| Keywords | b cells; clinical immunology; immune deficiencies |
| Attached files | |
| Description | Primary antibody deficiencies (PAD) constitute the majority of all primary immunodeficiency diseases (PID) also termed inborn errors of immunity (IEI). This category (PAD) represents around 52% of all IEI and the proportion overall is still greater given that antibody deficiency is a component of other groups including combined and severe combined immunodeficiencies (SCID), autoinflammatory disorders, diseases of immune dysregulation and other well-defined PIDs.1 Secondary antibody deficiencies (SAD) represent a larger and expanding number of individuals resulting from the use of a wide range of immunosuppressive therapies, in particular those targeting B cells, and may also result from renal or gastrointestinal immunoglobulin losses, infections, for example, HIV or malaria, malnutrition or others. |