Medical algorithm: Diagnosis and management of antibody immunodeficiencies


SEDIVA Anna MILOTA Tomas LITZMAN Jiří QUINTI Isabella MEYTS Isabelle BURNS Siobhan JOLLES Stephen

Year of publication 2021
Type Article in Periodical
Magazine / Source Allergy
MU Faculty or unit

Faculty of Medicine

Keywords b cells; clinical immunology; immune deficiencies
Attached files
Description Primary antibody deficiencies (PAD) constitute the majority of all primary immunodeficiency diseases (PID) also termed inborn errors of immunity (IEI). This category (PAD) represents around 52% of all IEI and the proportion overall is still greater given that antibody deficiency is a component of other groups including combined and severe combined immunodeficiencies (SCID), autoinflammatory disorders, diseases of immune dysregulation and other well-defined PIDs.1 Secondary antibody deficiencies (SAD) represent a larger and expanding number of individuals resulting from the use of a wide range of immunosuppressive therapies, in particular those targeting B cells, and may also result from renal or gastrointestinal immunoglobulin losses, infections, for example, HIV or malaria, malnutrition or others.

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