Antikoagulační terapie - známe její interakce?

Title in English Anticoagulant therapy - do we know its interactions?


Year of publication 2021
Type Article in Periodical
Magazine / Source Geriatrie a gerontologie
MU Faculty or unit

Faculty of Medicine

Keywords warfarin; Anticoagulant therapy; dabigatran; rivaroxaban; direct oral anticoagulants; drugs interactions; edoxaban; apixaban
Description Anticoagulant therapy is one of the key substances in medicine for its ability to reduce blood clotting. For many years it was coumarin derivatives that formed the pillar of anticoagulant therapy. They are now being displaced by direct oral anticoagulants (DOAC). It is a known fact, that the use of warfarin has a number of disadvantages, such as low therapeutic index with the need for frequent laboratory checks of treatment effectiveness, risk of bleeding, slow onset of action and long persistence of the effect after discontinuation. However, a major problem with anticoagulant therapy is that many patients forget their interaction with drugs and food. It is a great advantage of the DOAC group, especially in a geriatric patient with polypharmacotherapy, that their therapeutic effect is less influenced by interactions with food and medication.
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