Endocrine disrupting chemicals and their detection in an IVF laboratory

Authors

JEŠETA Michal FRANZOVÁ Kateřina MEKIŇOVÁ Lenka KISTANOVA Elena HARBULÁK Peter ŽÁKOVÁ Jana LOUSOVÁ Eva VENTRUBA Pavel CRHA Igor

Year of publication 2022
Type Article in Periodical
Magazine / Source Medical Journal of Cell Biology
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.2478/acb-2021-0023
Keywords bisphenol; reproduction; endocrine disruptors; oocyte; spermatozoa
Description The endocrine disruptors are chemicals with the capacity to influence physiological processes in the or-ganism, most often through hormonal control. They are present in the environment and in the products of daily use. They are often found in food, released from plastic bottles for water, present in cosmetics or fertilizers. Latest research suggests that they can be released from plastics used in the IVF laboratories and can be even present in the manipulation and cultivation media used for isolation and fertilization of gametes and subsequent cultivation of embryos. Permanent and long-term utilization of these substan-ces has adverse effects in human reproductive health, mainly by the means of interfering with synthesis and action mechanisms of reproductive hormones. Moreover, some endocrine disruptors show a range of adverse effects directly on the gametes or embryos cultured in the in vitro conditions. The article provides an overview on bisphenols detected in plastics and media commonly used in the IVF laboratory and consi-ders their possible impact on effectiveness of the IVF methods in a human laboratory.

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