Primary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients

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Authors

TAJ M.M. MAECKER-KOLHOFF B. LING R. BOMKEN S. BURKHARDT B. CHIANG A.K.S. CSOKA M. FUREDER A. HAOUY S. LAZIC J. MIAKOVA N. MINARD-COLIN V. TURNER Suzanne Dawn UYTTEBROECK A. ATTARBASCHI A.

Year of publication 2021
Type Article in Periodical
Magazine / Source British journal of haematology
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://onlinelibrary.wiley.com/doi/10.1111/bjh.17398
Doi http://dx.doi.org/10.1111/bjh.17398
Keywords central nervous system; outcome; post- transplant lymphoproliferative disorder; transplant; treatment
Description Primary central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty-five patients were retrieved from nine European Intergroup for Childhood Non-Hodgkin's Lymphoma and/or international Berlin-Frankfurt-Munster Study Group members. Types of allografts included kidney (n = 11), liver (n = 4), heart (n = 5), bowel (n = 1) and haematopoietic stem cells (n = 4). Eighteen were male, 16 >= 10 years old, 21 had monomorphic disease and 24 solid intracranial tumour masses. Four-year event-free and overall survival rates were 50% +/- 10% and 74% +/- 9% respectively. This report represents the largest paediatric series of CNS PTLD reported to date, showing favourable survival odds following systemic and intrathecal chemotherapy and rituximab administration.

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