DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs

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Authors

PERDIKOPANIS N. GEORGAKILAS Georgios GRIGORIADIS D. PIERROS V. KAVAKIOTIS I. ALEXIOU Panagiotis HATZIGEORGIOU A.

Year of publication 2021
Type Article in Periodical
Magazine / Source Nucleic acids research
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://academic.oup.com/nar/article/49/D1/D151/6007663
Doi http://dx.doi.org/10.1093/nar/gkaa1060
Keywords ANALYSIS GENE-EXPRESSIONDNA ELEMENTSENCYCLOPEDIA
Description Deregulation ofmicroRNA (miRNA) expression plays a critical role in the transition from a physiological to a pathological state. The accurate miRNA promoter identification in multiple cell types is a fundamental endeavor towards understanding and characterizing the underlying mechanisms of both physiological as well as pathological conditions. DIANA-miRGen v4 (www.microrna.gr/ mirgenv4) provides cell type specific miRNA transcription start sites (TSSs) for over 1500 miRNAs retrieved from the analysis of >1000 cap analysis of gene expression (CAGE) samples corresponding to 133 tissues, cell lines and primary cells available in FANTOM repository. MiRNA TSS locations were associated with transcription factor binding site (TFBSs) annotation, for >280 TFs, derived from analyzing the majority of ENCODE ChIP-Seq datasets. For the first time, clusters of cell types having common miRNA TSSs are characterized and provided through a user friendly interface with multiple layers of customization. DIANA-miRGen v4 significantly improves our understanding of miRNA biogenesis regulation at the transcriptional level by providing a unique integration of high-quality annotations for hundreds of cell specific miRNA promoters with experimentally derived TFBSs.
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