Izolovaná infiltrace ledviny suspektními leukemickými buňkami - kazuistika s komplexní diferenciální diagnostikou neobvyklého stavu

Authors

VIČAR Petr WEINBERGEROVÁ Barbora KREJČÍ Marta ŽÁČKOVÁ Daniela PODSTAVKOVÁ Natália DIVÁCKÁ Petra HOTÁRKOVÁ S SVOBODOVÁ Iva BEDNAŘÍK Zdeněk KAMARÁDOVÁ K. BORSKÝ Marek JEŽÍŠKOVÁ Ivana DOUBEK Michael HERMANOVÁ Markéta KRÁL Zdeněk MAYER Jiří

Year of publication 2022
Type Article in Periodical
Magazine / Source Transfuze a hematologie dnes
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.48095/cctahd2022prolekare.cz5
Keywords acute kidney injury; acute myeloid leukaemia; fever of unknown origin; kidney leukemic infiltration; myelosarcoma; tubulointerstitial nephritis
Attached files
Description This article describes a case of highly suspected isolated diffuse kidney infiltration by myeloid leukemic cells, without primary bone marrow involvement or any pathological imaging findings in a patient presenting with fever of unknown origin, acute kidney injury, microcytic anaemia, weight loss, anorexia, dry cough and mild splenomegaly. This complex diagnostic process thus required repeated biopsy of both bone marrow and kidney, which subsequently ruled out leukemic infiltration. The presenting symptoms and pathological laboratory findings responded promptly to corticosteroid treatment, and our patient was finally diagnosed with tubulointerstitial nephritis.

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