Depressive-like phenotype enhances relapse of nicotine seeking after forced abstinence in rats

Authors

AMCHOVÁ Petra RUDÁ Jana

Year of publication 2022
Type Article in Periodical
Magazine / Source The World Journal of Biological Psychiatry
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.tandfonline.com/doi/full/10.1080/15622975.2022.2070665
Doi http://dx.doi.org/10.1080/15622975.2022.2070665
Keywords abuse; depression; nicotine; olfactory bulbectomy; rats; self-administration
Description Comorbidity of depression and drug addiction is common, but effective treatment is missing. A rat model combining the olfactory bulbectomy (OBX) model and IV drug self-administration has provided evidence of differential reactivity of the OBX rats towards drugs of abuse. This study evaluates nicotine taking and seeking behavior in this model.
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