Depressive-like phenotype enhances relapse of nicotine seeking after forced abstinence in rats
| Authors | |
|---|---|
| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | The World Journal of Biological Psychiatry |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.tandfonline.com/doi/full/10.1080/15622975.2022.2070665 |
| Doi | http://dx.doi.org/10.1080/15622975.2022.2070665 |
| Keywords | abuse; depression; nicotine; olfactory bulbectomy; rats; self-administration |
| Description | Comorbidity of depression and drug addiction is common, but effective treatment is missing. A rat model combining the olfactory bulbectomy (OBX) model and IV drug self-administration has provided evidence of differential reactivity of the OBX rats towards drugs of abuse. This study evaluates nicotine taking and seeking behavior in this model. |
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