Fyzikálně-chemické vlastnosti kolistinu a jejich dopady do klinické praxe

Title in English Physico-chemical properties of colistin and their impact on clinical practice


Year of publication 2022
Type Article in Periodical
Magazine / Source Klinická farmakologie a farmacie
MU Faculty or unit

Faculty of Medicine

Web https://www.klinickafarmakologie.cz/pdfs/far/2022/01/06.pdf
Keywords colistin; stability; nebulization; adsorption; LC-MS
Description Colistin, a lipopeptide antibacterial agent, has a narrow-spectrum bactericidal activity only against gram-negative bacteria. It is administered as an inactive prodrug - colistin methanesulphonate, which is spontaneously converted to the active colistin. Its stability is concentration-, temperature-, and pH-dependent; moreover, the type of the carrier solution also plays a role. The stability of the colistin prodrug solutions has several implications for clinical practice, whether in intravenous or inhalation administration. Appropriate storage and properly selected type of test tubes and laboratory equipment are essential in therapeutic drug monitoring procedures. The aim of this paper is to emphasize several aspects for safe and effective colistin use and therapeutic monitoring.
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