1,5-dicaffeoylquinic acid, an antioxidant component of Cynara cardunculus leaves
| Authors | |
|---|---|
| Year of publication | 1999 |
| Type | Article in Periodical |
| Magazine / Source | Scripta Medica (BRNO) |
| MU Faculty or unit | |
| Citation | |
| Field | Organic chemistry |
| Description | This study describes the isolation, identification and some antioxidant properties of 1,5-dicaffeoylquinic acid. The title compound was isolated from the methanolic extract of the leaves of Cynara cardunculus. The isolation was based on the selective extraction of 1,5-dicaffeoylquinic acid with diethylether from weakly acidic water-methanolic solution and on column chromatography. Its structure was elucidated by 1D and 2D H-NMR spectroscopy. Inhibition of hemolysis induced by hydrogen peroxide and the antiradical effect of both 1,5-dicaffeoylquinic acid and cynarin (1,3-dicaffeoylquinic acid) were studied. Cynarin is formed from 1,5-dicaffeoylquinic acid by transesterification during the solvent extraction. Antioxidant activity of dicaffeoylquinic acids in both systems was stronger than that of ascorbic acid. |