Contrast-Enhanced Ultrasonography for Differential Diagnosis of Benign and Malignant Thyroid Lesions: Single-Institutional Prospective Study of Qualitati-ve and Quantitative CEUS Characteristics.

Authors

PETRÁŠOVÁ Hana ŠLAISOVÁ Radka ROHAN Tomáš STARÝ Karel KYCLOVÁ Jitka PAVLÍK Tomáš KOVALČÍKOVÁ Petra KAZDA Tomáš VÁLEK Vlastimil

Year of publication 2022
Type Article in Periodical
Magazine / Source CONTRAST MEDIA & MOLECULAR IMAGING
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.hindawi.com/journals/cmmi/2022/8229445/
Doi http://dx.doi.org/10.1155/2022/8229445
Keywords FINE-NEEDLE-ASPIRATION; ULTRASOUND CEUS; NODULES; SOLITARY; CANCER; PREVALENCE; GUIDELINES; PROSTATE; RISK
Description Objectives. To extend and revise the diagnostic value of contrast-enhanced ultrasonography (CEUS) for differentiation between malignant and benign thyroid nodules. Methods. This single-institution prospective study aims to compare CEUS qualitative and objective quantitative parameters in benign and malignant thyroid nodules. Consecutive cohort of 100 patients was examined by CEUS, 68 out of them were further analysed in detail. All included patients underwent cytological and/or histopathological verification of the diagnosis. Results. Fifty-five (81%) thyroid nodules were benign, and 13 (19%) were malignant. Ring enhancement pattern was strongly associated with a benign aetiology (positive predictive value 100%) and heterogeneous enhancement pattern with malignant aetiology (positive predictive value 72.7%). The shape of the TIC (time-intensity curve) was more often identical in the benign lesion (98.2%) than in malignant lesions (69.2%), p=0.004. Conclusions. This study indicates that CEUS enhancement patterns were significantly different in benign and malignant lesions. Ring enhancement was a very strong indicator of benign lesions, whereas heterogeneous enhancement was valuable to detect malignant lesions.

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