Can different type of the pressure ulcers debridement aff ect oxidative stress parameters?
|Year of publication||2022|
|Type||Article in Periodical|
|Magazine / Source||Česká a slovenská neurologie a neurochirurgie|
|MU Faculty or unit|
|Keywords||debridement; pressure ulcer; pressure injury; Versajet hydrosurgery system; oxidative stress parameters|
|Description||Wound debridement is one of the crucial steps in wound bed preparation for surgical closure. Various debridement forms and tools can be employed. Aim: The prospective case series study aimed to compare the impact of two different types of debridement on oxidative stress parameters. Material and methods: This study included five patients with pressure ulcers of deep category various localisation. The wound was divided into halves. In one, the sharp debridement was performed, in the second Hydrosurgery Versajet® debridement was accomplished. Tissue, blood and urine samples were collected on days 0 and 7 after the surgery. Histopathological evaluation in tissue samples was performed. Oxidative stress parameters in plasma and urine were evaluated. Results: Differences in quality and quantity of granulation tissue between two types of debridement were found. An insignificant decrease of oxidative stress markers in blood plasma and urine 7 days after surgery were observed. Conclusions: Preliminary and pilot results suggest that the wound healing process is closely associated with markers of oxidative stress that are measurable in blood plasma and urine. These could be indicative of the healing process. A nonsignificant decrease was observed for all oxidative stress parameters on day 7 after the surgery. The pilot study will be followed by a detailed molecular biological analysis of tissue samples.|