The advantage of PCR method in monitoring of specific chromosomal aberration in children with acute myeloid leukaemia
| Authors | |
|---|---|
| Year of publication | 1999 |
| Type | Article in Proceedings |
| Conference | Cells |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | acute myeloid leukemia |
| Description | Eighty percent of children with AML show clonal chromosomal aberrations on cytogenetic examination. The most frequent aberrations rexognised in AML are t(8;21), t(15;17), inv(16) and 11q23. These aberrations comprise 10-45% of all AML cases in choldren. Recently, the molecular genetic examination of these specific changes is available with the sensitivity of finding one leukemic cell bearing the translocation in between 1 million of normal cells. |
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