Vliv hormonální antikoncepce na kardiovaskulární systém

Title in English Effects of hormonal contraception on cardiovascular system


Year of publication 2022
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Medicine

Description Despite low concentrations of exogenous estrogens in contemporary monophasic oral contraceptive pills (OCP), there is still a number of side effects. That is why the aim of this study was to detect negative impact of OCP on cardiovascular system. 24 participants were divided into two groups – OCP+ group A (14 women; age: 21.0±1.3 y) and control group B (10 women; age: 21.5±1.5 y). Participants were divided into subgroups based on the phase of their menstrual cycle. Measurement devices VaSera (Fukuda Denshi, Japan) and SphygmoCor (AtCor Medical, Australia) were used. We measured systolic and diastolic blood pressure (SBP, DBP), Cardio-ankle vascular index (CAVI), carotid-radial pulse wave velocity (crPWV), and subendocardial viability index (SVI). We used Statistica 13.5 for statistical analysis of the data. All of the measured cardiovascular parameters were considered physiological for both experimental groups. Following parameters showed statistically significant difference between groups A and B: DBP (75.5±5.1 mmHg vs. 62.0±8.1 mmHg; p<0.01), SVI (160.0±13.1 % vs. 177.3±13.8 %; p<0.01), crPWV (7.0±0.8 m/s vs. 6.6±0.7 m/s; p<0.05). Comparison of other cardiovascular parameters between the groups showed no significant differences. Our results imply negative impact of OCP on cardiovascular health of their users. As both DBP and crPWV are affected mostly by the condition of peripheral arteries, we assumed that OCP affects mostly peripheral parts of the cardiovascular system. The significant decrease of SVI in OCP users also implies negative effects on the central part of the cardiovascular system.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info