Healthy Microbiome - A Mere Idea or a Sound Concept?

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Year of publication 2022
Type Article in Periodical
Magazine / Source Physiological research
MU Faculty or unit

Faculty of Science

Keywords Holobiont; Core microbiome function; Resilience; Microbiome ecology; One health hypothesis; Dysbiosis
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Description Hundreds of studies in last decades have aimed to compare the microbiome of patients suffering from diverse diseases with that of healthy controls. The microbiome-related component was additionally identified in pathophysiology of many diseases formerly considered to depend only on the host physiology. This, however, opens important questions like: "What is the healthy microbiome?" or "Is it possible to define it unequivocally?". In this review, we describe the main hindrances complicating the definition of "healthy microbiome" in terms of microbiota perspective of classical ecology and we advocate for the shift the specific context like the age, genetics, dietary habits, body site or physiological state.
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