Gastrointestinální projevy primárních imunodeficiencí
| Title in English | Gastrointestinal manifestation of primary immunodeficiency |
|---|---|
| Authors | |
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Alergie |
| MU Faculty or unit | |
| Citation | |
| Field | Immunology |
| Keywords | primary immune deficiency; common variable immunodeficiency; atrophic gastritis; hepatopathy; recurrent diarrhoea |
| Description | Gastrointestinal symptoms are frequent in primary immunodeficiency diseases. Severe chronic diarrhoea may be a first symptom of combined (T+B) immunodeficiency. In humoral immunodeficiencies, gastrointestinal symptomatology is most frequently met in common variable immunodeficiency (CVID). These patients suffer from atrophic gastritis with onset in a young age, gastritis probably predisposes to a gastric cancer which is also frequent in CVID patients. In a case of chronic diarrhoea infection of Giardia lamblia should be suspected. Chronic or recurrent diarrhoeas can also be observed in other humoral immunodeficiencies. Non-specific inflammatory bowel diseases seem to be more frequent in patients with humoral immunodeficiencies than in general population, unusual histopathologic findings can be observed in some cases. Hepatobiliary diseases in agammaglobulinemic patients are frequently associated with immunoglobulin replacement treatment. Some patients were infected by the hepatitis C virus from contaminated batches of intravenous immunoglobulins, but abnormal liver function tests were also observed in many patients without any laboratory signs of hepatitis-C virus infection. |
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