Cytotoxic effects of colicins E1 and E3 on v-myb-transformed monoblasts
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Folia Biologica |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | colicin; proliferation; cee death; v-myb; monoblasts |
| Description | Colicins show a considerable cytostatic activity. In this communication, the cytotoxic effects of colicins E1 and E3 on v-myb-transformed chicken monoblasts BM2 are presented. We detected clear reduction of the viable cell number induced by colicin E1 and E3, occuring without apparent changes in cell cycle profiles. The level of inhibition was proportional to colicin concentration. This result documents tha colicins exert their cytotoxic effects on leukemic cells. |
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