v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Proceedings |
| Conference | The 17th annual meeting on oncogenes |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Fos |
| Description | The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells to mature blood cells. To gain insights into the role of fos/jun in leukemogenicity, we expressed v-fos and v-jun in the line of chicken monoblasts BM2. We found that either v-fos or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. This suggests that oncogenic forms of Jun adn Fos proteins can further enforce v-Myb transformation. |
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