Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells

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Authors	DVOŘÁKOVÁ Dana KREJČÍ Pavel MAYER Jiří FAJKUS Jiří HAMPL Aleš DVOŘÁK Petr
Year of publication	2001
Type	Article in Periodical
Magazine / Source	British Journal of Haematology
MU Faculty or unit	Faculty of Informatics
Citation
Field	Oncology and hematology
Keywords	fibroblast growth factor receptor 3; chronic myeloid leukaemia; stem cell transplantation; BCR/ABL; prognosis
Description	Patients suffering from CML express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. FGFR3 expression became upregulated again in patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia.
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