Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Proceedings |
| Conference | International Congress 2001: "Severe Debilitating diseases". Abstract Book. |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | Pharmacogenetics; genetic polymorphism; cytochrome P 450 2D6; depressive disorder; adverse effects; |
| Description | Adverese effects of the long-term therapy with SSRI antidepressants including sexual disorders may be more pronounced in patients with decreased activity of CYP 2D6, either given by the defect of the enzyme expression or evoked by previous treatment with enzyme inhibitors. |
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