T-lymphocytes in IgA deficiency


LITZMAN Jiří ŠTOURAČOVÁ Martina KREJČÍ Marcela THON Vojtěch LOKAJ Jindřich

Year of publication 2001
Type Article in Periodical
Magazine / Source Scripta Medica
MU Faculty or unit

Faculty of Medicine

Field Immunology
Keywords IgA deficiency; T lymphocytes; lymphocyte subsets
Description Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with probably similar genetic background, but clinical and laboratory manifestation is much more severe in CVID than in IgAD. The aim of this study was to determine whether some abnormalities in T-lymphocyte subsets or function previously observed in CVID are also present in IgAD patients. T-lymphocyte subsets (CD3, CD4, CD8, CD4CD45RA, CD4CD45RO, CD8CD57) were studied in 61 adult IgAD patients and 43 control healthy persons. A significant decrease in CD4+ and increase in CD8+ and CD8+CD57+ lymphocytes was observed, while no significant changes in the proportion of CD45RA+ or CD45RO+ in CD4 cells were detected. No significant changes in lymphocyte proliferation after stimulation with Phytohaemagglutinin, Concanavalin-A or tetanic toxoid were observed in 15 adult IgAD patients compared to 15 controls. Our study shows, that T-lymphocyte abnormalities are also present in IgAD patient, although not in such a broad extent as in CVID.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info