Klinický význam CYP 2D6 v průběhu léčby novějšími antidepresivy

Title in English Clinical Significance of CYP 2D6 During Treatment with Recent Antidepressants

ŽOURKOVÁ Alexandra

Year of publication 2002
Type Article in Periodical
Magazine / Source Česká a slovenská psychiatrie
MU Faculty or unit

Faculty of Medicine

Field Neurology, neurosurgery, neurosciences
Keywords poor metabolizer;extensive metabolizer;CYP 2D6;phenotypic conversion;side-effects
Description The paper presents the results of treatment of 30 patients with residuals symptoms of clinical depression with paroxetine and mirtazapine in a double-blind study with monitoring of CYP 2D6.The results of the study show that as to the current tolerance of treatment by CYP 2D6 inhibitors,it is rather the value of metabolic phenotype than the genetically determined CYP 2D6 capacity taht has informative value.
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