Relationship Between CYP 2D6 Metabolic Status and Sexual Dysfunction in Paroxetine Treatment



Year of publication 2002
Type Article in Periodical
Magazine / Source Journal of Sex and Marital Therapy
MU Faculty or unit

Faculty of Medicine

Field Psychiatry, sexuology
Keywords sexual dysfunction; CYP2D6; paroxetine; poor metabolizer
Description This article describes the incidence of sexual dysfunction in 30 patients subjected to long-term treatment by paroxetine in dependence on the P 450 CYP 2D6 isoenzyme metabolic status. Measured on the Arizona Sexual Experience Scale (ASEX; McGahuey, Delgado, & Gelenberg, 1999), the incidence of sexual dysfunction inpatients converted to CYP 2D6 poor metabolizers was markedly higher compared with patients who had no history of such conversion, a difference that reached the level of statistical significance. Our article discusses the incidence of sexual dysfunction in connection with reduced CYP 2D6 capacity.
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