Acetylační polymorfismus a psychiatrická onemocnění

Title in English Acetylation polymorphism and psychiatric diseases


Year of publication 2002
Type Article in Periodical
Magazine / Source Klinická farmakologie a farmacie
MU Faculty or unit

Faculty of Medicine

Field Pharmacology and pharmaceutical chemistry
Keywords Acetylator phenotype; N-acetyltransferase; schizofrenia; depressive disorders
Description N-acetylating capacity was determined in 61 patients with schizophrenia and 49 patients with depressive disorder using sulphadimidine phenotyping test. The results were compared with those within the group of 51 healthy volunteers. In patients with schizophrenia there was increased occurence of slow acetylators (68.8 % SA) in comparison with healthy individuals 58.8 % SA) as well as with patients with depression (55.1 % SA). Preponderance of SA in psychotic patients may be a cause of a higher risk of therapy with substrate drugs.
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