UVC-Protective Effect of Caffeic Acid on Normal and Transformated Human Skin Cells in Vitro
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Folia Biologica |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | UVC; caffeic acid; UV-protective effect; alpha-tocopherol |
| Description | Possible UVC-protective properties of caffeic acid (CA), a plant phenolic compound with antioxidant activity, were investigated on human KF1 diploid fibroblast and A431 epidermoid carcinoma cell lines. Cell populations, untreated and treated by antioxidants (CA and á-tocopherol), were irradiated by UVC at the wavelength of 254 nm and their proliferation activity was determined by the MTT-assay. Results show a strong protective effect of CA at both concentrations used (55.5 and 165.5 ěM). This protective ability is probably based on the antioxidant and scavenging activities of CA, which seems to be more efficient than á-tocopherol in protection against cytotoxic effect caused by UVC-irradiation. |
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