Faktory podílející se na vzniku varikozního krvácení při portální hypertenzi- I. část: bakteriální infekce a porovnání účinnost intravenózního a perorálního podání antibiotik - randomizovaná studie
| Title in English | Factors Participating in Development of Bleeding Varices in Portal Hypertenzion. Part I: Bacterial Infection and Comparison of Intravenous and Peroral Antibiotics Effects - A Randomized Study. |
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| Authors | |
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Vnitřní lékařství |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | Cirrhosis of the liver - Portal hypertension - Bleeding oesophageal varices - Bacterial infection -- Antibiotic treatment |
| Description | An acute bleeding from oesophageal varices as a result of portal hypertension is a frequent and at the same time serious complication of cirrhosis of the liver. One of factors influencing this bleeding can be a bacterial infection.Endotoxines can increase portal pressure and so participate in development of bleeding and simultaneously deteriorate a patients prognosis. An antibiotic treatment is a part of a treatment algorithem, however what antibiotics to administer and in what manner is ulclear. A group of 46 patients who were admitted to a hospital for an acute bleeding from varices has been compared in the study 48 cirrhosis patients hospitalised for other reasons.There was no difference in survival of both groups. Due to a high number of bacterial infections antibiotics administration has been indicated in these patients. Intravenous administration is probably of the same effect as peroral administration. |
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