Faktory podílející se na vzniku varikozního krvácení při portální hypertenzi- I. část: bakteriální infekce a porovnání účinnost intravenózního a perorálního podání antibiotik - randomizovaná studie

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Title in English Factors Participating in Development of Bleeding Varices in Portal Hypertenzion. Part I: Bacterial Infection and Comparison of Intravenous and Peroral Antibiotics Effects - A Randomized Study.
Authors

LATA Jan JURÁNKOVÁ J. HUSOVÁ Libuše ŠENKYŘÍK Michal DÍTĚ Petr DASTYCH Milan

Year of publication 2004
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Informatics

Citation
Field Other specializations of internal medicine
Keywords Cirrhosis of the liver - Portal hypertension - Bleeding oesophageal varices - Bacterial infection -- Antibiotic treatment
Description An acute bleeding from oesophageal varices as a result of portal hypertension is a frequent and at the same time serious complication of cirrhosis of the liver. One of factors influencing this bleeding can be a bacterial infection.Endotoxines can increase portal pressure and so participate in development of bleeding and simultaneously deteriorate a patients prognosis. An antibiotic treatment is a part of a treatment algorithem, however what antibiotics to administer and in what manner is ulclear. A group of 46 patients who were admitted to a hospital for an acute bleeding from varices has been compared in the study 48 cirrhosis patients hospitalised for other reasons.There was no difference in survival of both groups. Due to a high number of bacterial infections antibiotics administration has been indicated in these patients. Intravenous administration is probably of the same effect as peroral administration.
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