Faktory podílející se na vzniku varikozního krvácení při portální hypertenzi- I. část: bakteriální infekce a porovnání účinnost intravenózního a perorálního podání antibiotik - randomizovaná studie


This publication doesn't include Faculty of Medicine. It includes Faculty of Informatics. Official publication website can be found on muni.cz.

Title in English Factors Participating in Development of Bleeding Varices in Portal Hypertenzion. Part I: Bacterial Infection and Comparison of Intravenous and Peroral Antibiotics Effects - A Randomized Study.


Year of publication 2004
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Informatics

Field Other specializations of internal medicine
Keywords Cirrhosis of the liver - Portal hypertension - Bleeding oesophageal varices - Bacterial infection -- Antibiotic treatment
Description An acute bleeding from oesophageal varices as a result of portal hypertension is a frequent and at the same time serious complication of cirrhosis of the liver. One of factors influencing this bleeding can be a bacterial infection.Endotoxines can increase portal pressure and so participate in development of bleeding and simultaneously deteriorate a patients prognosis. An antibiotic treatment is a part of a treatment algorithem, however what antibiotics to administer and in what manner is ulclear. A group of 46 patients who were admitted to a hospital for an acute bleeding from varices has been compared in the study 48 cirrhosis patients hospitalised for other reasons.There was no difference in survival of both groups. Due to a high number of bacterial infections antibiotics administration has been indicated in these patients. Intravenous administration is probably of the same effect as peroral administration.
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