Cannabinoids did not affect sensitization to methamphetamine in rats


LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra

Year of publication 2005
Type Article in Periodical
Magazine / Source The World Journal of Biological Psychiatry
MU Faculty or unit

Faculty of Medicine

Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; cannabinoids; methamphetamine; rats
Description Obtained data clearly demonstrated that as previously in mice a repeated administration of methamphetamine elicited behavioural sensitization to its stimulatory effects in rats. However, we were not able to provoke cross-sensitization by repeated application of cannabinoid CB1 receptor agonist methanandamide and similarly, we did not demonstrate suppression of the cross-sensitization in rats that were repeatedly given combined pre-treatment of cannabinoid CB1 receptor antagonist AM 251 and methamphetamine as it was demonstrated in research carried out in mice.
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