Extáze zvyšuje plachost a snižuje agresivitu v sociálních interakcích myší

Title in English MDMA increases timidity and decreases agressivity in social interactions in mice

ŠLAIS Karel LANDA Leoš ŠULCOVÁ Alexandra

Year of publication 2005
Type Article in Periodical
Magazine / Source Československá fyziologie
MU Faculty or unit

Faculty of Medicine

Field Pharmacology and pharmaceutical chemistry
Keywords MDMA; agonistic interactions; mice; behavioural study; anxiety; anxiogenic effects
Description We analyzed behavioural changes in 15 acts of 4 categories: sociable, timid, aggressive and locomotor. Mice were administered MDMA at the doses of 2.5 or 10 or 30 mg/kg, or saline in the equal amount of 1ml/kg, orally. Paired interactions were videotaped and ethological analysis was performed. In aggressive mice, MDMA in all tested doses caused highly significant inhibition of all aggressive activities with the significant increase of sociability and defensive-escape behaviour and at the highest dose also of walking. In timid mice, the most significant changes were in increase of defensive-escape behaviour and decrease of sociable activities; just the highest dose stimulated significantly walking.
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