Age-dependent relationship between the carotid intima-media thickness, baroreflex sensitivity, and the inter-beat interval in normotensive and hypertensive subjects.
|Year of publication||2005|
|Type||Article in Periodical|
|Magazine / Source||Physiological Research|
|MU Faculty or unit|
|Keywords||Intima-media thickness; baroreflex sensitivity; hypertension; age; heart rate|
|Description||The interrelationship between baroreflex sensitivity expressed in ms/mmHg (BRS) or in Hz/mmHg (BRSf), carotid wall thickness (IMT), and age was investigated in 25 treated hypertensives and 23 normotensives with respect to the mean inter-beat interval (IBI) and blood pressure (BP). IMT was measured by ultrasonography. BRS and BRSf were determined by the spectral method (five-minute non-invasive beat-to-beat recording of BP and IBI, Finapres). Hypertensive patients have significantly increased IMT and decreased BRS and BRSf. The positive correlation between age and IMT and the negative correlation between age and BRS and BRSf are in agreement with the hypothesis that the age-dependent decrease of baroreflex sensitivity corresponds to the age-related structural changes of the carotid wall. Using two indices of baroreflex sensitivity, BRS and BRSf, we could show that baroreflex sensitivity in hypertensives is lower not only due to thickening of the carotid wall, but also due to aging.|