Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Clin Exp Immunol |
| MU Faculty or unit | |
| Citation | |
| Field | Immunology |
| Keywords | Common variable immunodeficiency; T-lymphocyte subsets; B-lymphocyte subsets; differentiation antigens; age factor |
| Description | Common variable immunodeficiency (CVID) is primary hypogammaglobulinemia with unknown etiopathogenesis. Although various abnormalities of T- and B-cells were described, their pathogenetic roles are unclear. Markers associated with B-cell development were determined on B-lymphocytes (CD19+); T-lymphocyte development and activations markers were determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were particularly observed in patients with a decreased number of memory (CD27+) and mature (CD21+) B-cells (group Ia according to Freiburg classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend on grouping patients together according to B-lymphocyte developmental subpopulations. The expression of CD27 and CD45RA on CD4+ T-lymphocytes, such as the percentage of IgD+CD27- and IgD+CD27+ cells in B-lymphocytes, showed age dependency to be more significant than in the control group. |
| Related projects: |