p53 induces differentiation but not apoptosis of v-myb-transformed monoblasts

Investor logo

Warning

This publication doesn't include Faculty of Medicine. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors

NAVRÁTILOVÁ Jarmila HORVÁTH Viktor KOZUBÍK Alois LOJEK Antonín ŠMARDA Jan

Year of publication 2006
Type Article in Proceedings
Conference International Journal of Molecular Medicine,
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Myb; p53; apoptosis; differentiation; monoblast
Description p53 is a tumor suppressor protein that protects cells from transformation. In contrast, the v-Myb oncoprotein of avian myeloblastosis virus (AMV) transforms myelomonocytic cells in vitro and induces acute myeloblastic leukemia in vivo. To examine functional interactions of the v-Myb and p53 proteins, we ectopically expressed human p53 in v-Myb-transformed chicken monoblasts BM2. The p53 protein arrested growth in G2 phase of the cell cycle and induced monocytic differentiation, but it did not cause programmed cell death of BM2 cells. Transcriptional activation by v-Myb was up-regulated by the p53 protein, as previously observed during the phorbol ester-induced differentiation of BM2 cells. These results demonstrate that p53 can alter the function of the v-Myb oncoprotein and thus suppress its transforming effect.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info