MDMA pre-treatment cross-sensitizes to methamphetamine stimulatory effects in mice
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | European Neuropsychopharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | behavioural sensitization; mice; ecstasy; methamphetamine |
| Description | Various psychostimulant drugs induce after their repeated administration a significant increase in behavioural responses, phenomenon known as behavioural sensitization. In our recent studies we demonstrated development of this phenomenon after repeated administration of methamphetamine (Met) and its expression following Met challenge dose after the withdrawal lasting 6 days. Furthermore, pretreatment with CB1 receptor agonist methanandamide elicited behavioural cross-sensitization to Met stimulatory effects. By analogy, we decided to test a possible cross-sensitization to Met with another widely abused substance - MDMA (ecstasy), and vice versa with Met repeated pretreatment to MDMA effects. |
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