p53 arrests growth and induces differentiation of v-myb-transformed monoblasts

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Authors

ŠMARDA Jan NAVRÁTILOVÁ Jarmila HORVÁTH Viktor KOZUBÍK Alois LOJEK Antonín

Year of publication 2007
Type Article in Proceedings
Conference Molecular Aspects of myeloid stem cell development and leukemia
MU Faculty or unit

Faculty of Science

Citation
Field Oncology and hematology
Keywords Myb; p53; differentiation; apoptosis; cell growth
Description Ectopic expression of human p53 in avian leukemic monoblasts BM2 induces cell cycle arrest in G2, early monocytic differentiation but no apoptosis. This suggests that the species-specific differences of the p53 molelecules,promoter/enhancers, co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilities of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein.
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