Blocking CB1 receptors - a promising approach for treatment of drug dependence ?


LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra

Year of publication 2007
Type Article in Proceedings
Conference Addiction and Eating Disorders Neurobiology and Comorbidities
MU Faculty or unit

Faculty of Medicine

Field Pharmacology and pharmaceutical chemistry
Keywords cannabinoids; CB1 receptor; open field test
Description In the group pre-treated with methamphetamine only, behavioural sensitization occurred, whereas in the group pre-treated with the combination of methamphetamine and selective CB1 receptor antagonist AM 251 behavioural responses were suppressed and locomotor activity in the open field was significantly reduced.
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