Blockade of CB1 cannabinoid receptor decreases the body weight without change of locomotor activity in mice


ŠLAIS Karel LANDA Leoš ŠULCOVÁ Alexandra

Year of publication 2007
Type Article in Proceedings
Conference Addiction and Eating Disorders Neurobiology and Comorbidities
MU Faculty or unit

Faculty of Medicine

Field Pharmacology and pharmaceutical chemistry
Keywords cannabinoids; CB1 receptor; open field test
Description Cannabinoid antagonist AM-251 decreased dose dependently body weight after repeated administration in mice. Locomotor activity was not affected, thus it can be hypothesized that the reduction of body weiht was due to anorectic effects of AM-251.
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