Stanovení exprese genu pro kanabinoidní CB1 receptor pomocí real time PCR v myším mezencefalu po senzitizaci metamfetaminem

Title in English Assessment of gene expression for cannabinoid CB1 receptor using real time PCR in mice mesencephalon after methamphetamine sensitization


Year of publication 2008
Type Article in Periodical
Magazine / Source Psychiatrie
MU Faculty or unit

Faculty of Medicine

Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; methamphetamine; CB1 receptor; real time PCR
Description Real-time PCR results showed increased CB1 mRNA expression after Met first dose followed by decrease in CB1 mRNA expression after the last dose of the repeated treatment. This suggests that methamphetamine administration can elicit changes on the genomic level at least in the mouse mesencephalon neurons, both, in animals after acute drug administration and sensitised animals.
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