Measurement of arterial pulse wave velocity support the suspicion of asymptomatic left ventricular dysfunction in hypertensive patients with metabolic syndrome or diabetes mellitus


ŠPÁC Jiří HANUŠ Josef SOUČEK Miroslav NĚMCOVÁ Helena

Year of publication 2007
Type Article in Periodical
Magazine / Source Artery Research
MU Faculty or unit

Faculty of Medicine

Field Cardiovascular diseases incl. cardiosurgery
Keywords arterial pulse wave velocity . metabolic syndrome
Description The aim of this study was to evaluate myocardial function and vascular wall elasticity using pulse wave velocity (PWV)between aorta and femoral artery in patients with hypertension and metabolic syndrome (MS) or type 2 diabetes mellitus(HT+DM).Results:Pts in both groups revealed normal systolic function of the LV(EF 65 % versus 61%),pts with HT+DM had higher values of the LV mass than the group with MS (44,9 v.s. 54,0 g/height2,7, p=0.005) Average values of PWV were lower in the group with MS than in HT+DM group(11,38m/s vs 12,79 m/s,p=0.002) as well as BNP(54,7 vs 141,12 pg/l, p=0.005)and NT pro BNP(66,5 vs 279,6 pg/l). In both groups of pts increased PWV was significantly correlated with TDI measurements indicating reduced diastolic function (PWV and E/Evm r = 0,698, p<0,001)and values of natriuretic peptides(PWV versus NT pro BNP r = 0,776, p<0,001).Conclusions:Arterial stiffness in hypertensive pts revealed some relation to the LV dysfunction. The measurment of the PWV may contribute to the prediction of LV diastolic dysfunction in hypertensive pts with metabolic syndrome or diabetes mellitus.
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