Impact of cannabinoid receptor ligands on sensitization to methamphetamine effects on rat locomotor behaviour


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LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra

Year of publication 2008
Type Article in Periodical
Magazine / Source Acta Veterinaria Brno
MU Faculty or unit

Faculty of Arts

Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; methamphetamine; cannabinoids; open field test; rats
Description Investigation in rats brought very resembling results described earlier in mice. However, there were registered at least some interspecies differences in the rat susceptibility to development of sensitization to methamphetamine effects. Comparing to mice it was more demanding to titrate a dose of methamphetamine producing behavioural sensitization. Furthermore we were not able to provoke cross-sensitization by repeated application of cannabinoid CB1 receptor agonist methanandamide and similarly, we did not demonstrate suppression of the cross-sensitization in rats that were repeatedly given combined pre-treatment with cannabinoid CB1 receptor antagonist AM 251 and methamphetamine. Finally, unlike the mice there was registered an alternative behavioural change after repeated methamphetamine treatment instead, the occurrence of stereotypic behaviour (nose rubbing).
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