Behavioural sensitization to methamphetamine affects expression of dopamine D1 receptors in mouse midbrain



Year of publication 2008
Type Article in Periodical
Magazine / Source The International Journal of Neuropsychopharmacology
MU Faculty or unit

Faculty of Medicine

Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; methamphetamine; dopamine D1 receptors; mice
Description The behavioural part of experiment showed stimulatory influence of methamphetamine (Met) after the acute administration and development of sensitization to Met after repeated treatment. Real-time PCR results showed increased D1 mRNA expression after Met first dose followed by further increase after the last dose of repeated treatment.
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