MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders

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Year of publication 2009
Type Article in Periodical
Magazine / Source Int J Immunogenet
MU Faculty or unit

Faculty of Medicine

Field Epidemiology, infectious diseases and clinical immunology
Keywords Allergy; CCR2; gene; MCP-1; polymorphism
Description Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analyzed polymorphisms at -2518A/G and -2076A/T of MCP-1 and V64I of CCR2 gene in healthy subjects (n=306) and allergic patients (n=332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population.
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