Methamphetamine behavioural senistization in rodents: interactions with selected drugs and gender.

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Authors

ŠULCOVÁ Alexandra KUČEROVÁ Jana LANDA Leoš PISTOVČÁKOVÁ Jana NOVÁKOVÁ Jana VRŠKOVÁ Dagmar

Year of publication 2008
Type Article in Periodical
Magazine / Source Adiktologie
MU Faculty or unit

Faculty of Arts

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords methamphetamine; MDMA; morphine
Description Different behavioural rodent models (rat i.v. drug self-administration, mouse agonistic behaviour, open field test,) were used. Behavioural sensitization to metamphetamine was ocnfirmed after repeated pretreatment with methpahetmaine itself but also after MDMA, morphine and cannabinoid CB1 receptor agonist. A higher rewarding effect of methamphetamine was noted in the sensitized animals with estrus-like conditions and attenuated by estrogen deprivation.
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