The effects of trimecaine on bupivacaine-induced cardiotoxicity in the isolated rat heart: a pilot study.



Year of publication 2008
Type Article in Periodical
Magazine / Source Physiological Research
MU Faculty or unit

Faculty of Medicine

Field Physiology
Keywords trimecaine;bupivacaine;isolated rat heart;arrhythmias
Description Introduction: trimecaine is methylated derivative of lidocaine and displaces bupivacaine from its receptor on the sodium channel. Animal trials showed increased threshold for bupivacaine-induced ventricular fibrillation in combination of lidocaine and bupivacaine. However, trials in isolated animal hearts did not confirm this positive effect of lidocaine and thus the role of local anesthetics in affecting bupivacaine-induced cardiotoxicity remains unclear. Methods: An isolated rat heart perfused at constant pressure according to Langendorff was used. Heart rate, coronary flow, PQ and QRS intervals were recorded. After 30 min of stabilization, the hearts were exposed to either bupivacaine or bupivaciane-trimecaine mixture for 30 min and then a period of washout for 30 min followed. Results: In spontaneously beating hearts, bupivacaine and bupivacaine-trimecaine mixture led to a significant decrease in heart rate, coronary flow and to an increase in PQ and QRS intervals. Due to small number of animals in this pilot study we can not demonstrate the significant difference between both groups. Conclusion: We followed the effects of different concentrations of bupivacaine and trimecaine in order to get starting information for future study with bigger number of animals to demonstrate the effect of lidocaine and trimecaine on bupivacaine-induced cardiotoxicity.

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