Progression of selective IgA deficiency to common variable immunodeficiency in a 16 year old boy.
| Authors | |
|---|---|
| Year of publication | 1996 |
| Type | Article in Periodical |
| Magazine / Source | Allergologia et immunopathologia |
| MU Faculty or unit | |
| Citation | |
| Field | Immunology |
| Keywords | IgA deficiency; CVID; |
| Description | A case report of a 16 year old boy in whom selective IgA deficiency progressed to typical common variable immunodeficiency (CVID) is described. This boy with a history of frequent but not severe respiratory tract infections was referred to hospital because of severe pleuropneumonia and decreased levels of IgA (0.23 g/L), but normal IgG and IgM levels. Lymphocyte subpopulation determination revealed a decreased proportion of CD4+ lymphocytes (30%) and an increased proportion of CD8+ lymphocytes (32%), while CD3+, CD19+ and CD16+/56+ subpopulations were normal. During the subsequent 17 months a gradual decrease in IgG (ultimate level 2.23 g/L), IgA (< 0.05 g/L) and IgM (< 0.05 g/L) levels was observed, the decrease in IgM being the slowest reflecting a constant heavy chain gene order on chromosome 14. The observation supports the thesis of a close relation of selective IgA deficiency and common variable immunodeficiency. |