HLA DRB1,DQB1 and insulin promoter VNTR polymorphisms:interactions and the association with adult-onset diabetes mellitus in Czech patiens
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | International Journal of immunogenetics |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | HLA DRB1 DQB1 |
| Description | Both the human leucocyte antigen (HLA) BRB1 and the HLA BRB1 gene loci play a role in the development and progression of autoimmune diabetes mellitus (T1DM).Similarly, the insulin promoter variable number tandem repeats (INS-VNTR) polymorphism is also involved in the pathogenesis of diabetes mellitus (DM). We studied the association between each of these polymorphisms and DM diagnosed in patients older than age 35 years. Furthermore, we analysed possible interactions between HLA BRB1/DQB1 and INS-VNTR polymorphisms. |