Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells

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Authors

NAVRÁTILOVÁ Jarmila JUNGOVÁ Pavla VAŇHARA Petr PREISLER Jan KANICKÝ Viktor ŠMARDA Jan

Year of publication 2009
Type Article in Periodical
Magazine / Source International Journal of Molecular Medicine
MU Faculty or unit

Faculty of Science

Citation
Field Oncology and hematology
Keywords disulfiram; copper; myeloid leukemia; cell density; inoculum effect; SALD ICP MS
Description In this study, we report the cell density-dependent induction of apoptosis of human acute myeloid leukemia U937 and ML-1 cells by disulfiram (DSF), the dithiocarbamate drug recently proposed for treatment of human cancers. This effect is dependent on uptake of extracellular copper and its intracellular accumulation.
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