Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI
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| Year of publication | 2009 |
| Type | Conference abstract |
| MU Faculty or unit | |
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| Description | Myocardial infarction (MI) following reparative processes include inflammatory cell infiltration, activation of matrix metalloproteinases (MMPs – family of Zn-dependent endopeptidases), extracellular matrix remodeling and scar formation. The goal of the study was the exploration of MMP-2 serum activity early after MI and its assocition with signs of acute heart failure (AHF), left ventricle systolic dysfunction, with hospital mortality and oxidative stress. Population and methods: A total of 311 patients (75% male, age 62,7 years) with acute MI with ST elevations treated by primary PCI (without AHF – 220 pts, with AHF 91 pts). Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA). MMP-2 (value B), Troponin I, BNP, NT-proBNP, malondialdehyd (MDA), TNF-alfa, vitamine A and E, uric acid were eveluated 24 hours after chest pain occurance. MMP-2 (value A) was also evaluated during admission before primary PCI, we count difference of MMP-2 (value A-B) during admission and after 24 hours. Left ventriculography was done and dP/dt/P and LVEDP was measured before primary PCI. |
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