Diagnostické a terapeutické perspektivy analýzy DNA u psoriázy
| Title in English | Díagnostic and therapeutic perspectives of DNA analysis in psoriasis |
|---|---|
| Authors | |
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Česko-slovenská dermatologie |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | psoriasis; polymorphism; SNP-gene; DNA; marker |
| Description | Etiopathogenesis of psoriasis includes four characteristic features - inflammation, hyperproliferation, of keratinocytes with their abnormal differentiation, hyperproliferation of endothelia and inhibition of keratinocyte apoptosis. Because of familial occurrence of psoriasis, a contribution of genetic factors to etiopathogenesis must be considered. As a result of statistical analysis of genotyping of psoriatic patients as well as control subjects in selected gene polymorphisms, several DNA markers for psoriasis were proved in the Czech population. There are genotypes AG and GG in 2184 G/A RAGE (advanced glycation end products receptor, odds ratio=2,25, P=0,00004) and the heterozygote genotype A/AA in A39526AA retinoid X receptor alfa polymorphism in women with psoriasis against the men with psoriasis (odds ratio=2,22, P=0,002). Further, the risk heterozygote genotype GA in polymorphism -596 G/A of interleukin 6 gene was found (odds ratio=1,83, P=0,008) for psoriatic patients with positive family history. All these risk genotypes can cause diferent responsiveness to psoriasis therapy. |