Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis

• Authors: MIKULKOVÁ Zuzana; PRAKSOVÁ Petra; ŠTOURAČ Pavel; BEDNAŘÍK Josef; ŠTRAJTOVÁ Lucie; PACASOVÁ Rita; BĚLOBRÁDKOVÁ Jana; DÍTĚ Petr; MICHÁLEK Jaroslav
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Cellular Immunology
• MU Faculty or unit: Faculty of Medicine
• Field: Immunology
• Keywords: Type 1 diabetes mellitus; Multiple sclerosis; Autoimmune diseases; Regulatory T-cells; Suppressor cells
• Description: Type 1 diabetes mellitus and multiple sclerosis are organ-specific autoimmune diseases leading to an attack of auto-aggressive lymphocytes against the pancreatic beta-cells and central nervous system, respectively. Using four-colour flow cytometry, T-lymphocyte populations having an important function in autoimmune processes were analyzed. The observed data demonstrate significant differences among patients with T1D and MS in comparison to healthy individuals.

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