Transactivation by temperature-dependent p53 mutants in yeast and human cells

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Authors

SLOVÁČKOVÁ Jana GROCHOVÁ Diana NAVRÁTILOVÁ Jarmila ŠMARDA Jan ŠMARDOVÁ Jana

Year of publication 2010
Type Article in Periodical
Magazine / Source Cell Cycle
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords p53; FASAY; transactivation
Description We analyzed transactivation of several p53-target genes by 23 temperature-dependent p53 mutants and stratified them into four functional groups. Seventeen mutants exhibited temperature-dependency and discriminative character in human and yeast cells. Our analysis showed that functional analysis of separated alleles in yeast is valuable tool for assessment of the human p53 status.
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