Funkční deficit pentózového cyklu jako důsledek abnormálního metabolizmu thiaminu ve vztahu k progresi diabetické nefropatie a k mortalitě

Title in English	Functionally deficient pentose phosphate pathway as a result of abnormal thiamine metabolism in relation to the progression of diabetic nephropathy and mortality
Authors	PÁCAL Lukáš TOMANDL Josef SVOJANOVSKÝ Jan KRUSOVÁ Darja ŠTĚPÁNKOVÁ Soňa OLŠOVSKÝ Jindřich BĚLOBRÁDKOVÁ Jana TANHÄUSEROVÁ Veronika TOMANDLOVÁ Marie ŘEHOŘOVÁ Jitka SMRŽOVÁ Jana HERTLOVÁ Miluše MUŽÍK Jan KAŇKOVÁ Kateřina
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Pentose phosphate pathway (PPP) represents a potentially protective pathway in hyperglycemia. Transketolase is the key enzyme of PPP. We aimed to find out whether parameters of thiamine metabolism can influence progression of diabetic nephropathy (DN) and morbidity of patients with DN.
Related projects:	Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy